Technology and Detection
Tomić S, Milcić N, Sokolić M, Martinac AI. Identification of counterfeit medicines for erectile dysfunction from an illegal supply chain. Arh Hig Rada Toksikol. 2010;61(1):69-75.
The appearance of counterfeit medicines in supply chains is a global public health problem that may seriously affect patients. Counterfeit drugs do not meet quality standards and do not declare their real composition and/or source for the purposes of fraud. They may be generic or innovative, they may contain genuine constituents in a fake packaging,…
[...]Dai XM, An N Wu JM, Li HY, Zhang QM. Development and Validation of HPLC-UV-MS method for the control of four anti-diabetic drugs in suspected counterfeit products. Yao Xue Xue Bao. 2010 Mar; 45(3):347-52.
An HPLC-UV method has been developed for the determination of valibose, miglitol, voglibose and acarbose, the four anti-diabetic drugs. The separation was accomplished successfully by using reversed phase chromatography (Prevail carbohydrate column, 250 mm x 4.6 mm, 5 microm) with a gradient acetonitrile-phosphate buffer solution (pH 8.0) at a wavelength of 210 nm. Furthermore, the…
[...]Twohig M, Skilton SJ, Fujimoto G, Ellor N, Plumb RS. Rapid detection and identification of counterfeit of adulterated products of synthetic phosphodiesterase type-5 inhibitors with an atmospheric solids analysis probe. Drug Test Anal. 2010;2(2):45-50.
The market success of the three approved synthetic phosphodiesterase type-5 (PDE-5) inhibitors for the treatment of erectile dysfunction has led to an explosion in counterfeit versions of these drugs. In parallel a large market has developed for herbal products claimed to be natural alternatives to these synthetic drugs. The herbal products are heavily advertised on…
[...]Erdem E, Zeng H, Zhou J, Shi J, Wells DL. Investigation of RFID tag readability for pharmaceutical products at item level. Drug Dev Ind Pharm. 2009;35(11):1312-24.
BACKGROUND: The applications of radio frequency identification (RFID) technology carry a tremendous potential for pharmaceutical industry. There is a pressing need to analyze the performance of RFID tags attached to various pharmaceutical dosage forms. METHOD: The readability of RFID-tagged pharmaceutical products is, for the first time, systematically investigated by experiments. Factors considered include dosage forms,…
[...]Hargreaves MD, Macleod NA, Smith MR, Andrews D, Hammond SV, Matousek P. Characterisation of transmission Raman spectroscopy for rapid quantitative analysis of intact multi -component pharmceuticals capsules. J Pharm Biomed Anal. 2011;54(3):463-8.
A detailed characterisation of the performance of transmission Raman spectroscopy was performed from the standpoint of rapid quantitative analysis of pharmaceutical capsules using production relevant formulations comprising of active pharmaceutical ingredient (API) and 3 common pharmaceutical excipients. This research builds on our earlier studies that identified the unique benefits of transmission Raman spectroscopy compared to…
[...]Puchert T, Lochmann D, Menezes JC, Reich G. Near-infrared chemical imaging (NIR-CI) for counterfeit drug identification–a four-stage concept with a novel approach of data processing (Linear Image Signature). J Pharm Biomed Anal. 2010;51(1):138-45.
A new stage concept was developed to reliably identify counterfeit tablets which are very similar to the genuine drug product. This concept combines single-point near-infrared spectroscopy (NIRS) and near-infrared chemical imaging (NIR-CI) with statistical variance analysis. The advantage of NIR-CI over NIRS is the potential to determine not only the amount, but also the spatial…
[...]Nyadong L, Harris GA, Balayssac S, Galhena AS, Malet-Martino M, Martino R, Parry RM, Wang MD, Fernández FM, Gilard V. Combining two-dimensional diffusion-ordered nuclear magnetic resonance spectroscopy, imaging desorption electrospray ionization mass spe
During the past decade, there has been a marked increase in the number of reported cases involving counterfeit medicines in developing and developed countries. Particularly, artesunate-based antimalarial drugs have been targeted, because of their high demand and cost. Counterfeit antimalarials can cause death and can contribute to the growing problem of drug resistance, particularly in…
[...]Trefi S, Routaboul C, Hamieh S, Gilard V, Malet-Martino M, Martino R. Analysis of illegally manufactured formulations of tadalafil (Cialis®) by 1H NMR, 2D DOSY 1H NMR and Raman spectroscopy. J Pharm Biomed Anal. 2008 May 12;47(1):103-113
Abstract. Counterfeit and/or imitation medicines are becoming a major health problem not only in developing countries but also in wealthier countries. The need of new and easy analytical methods for quality control of drugs is essential. We describe the use of Raman spectroscopy, 1H nuclear magnetic resonance (NMR) and 2D diffusion-ordered spectroscopy (DOSY) NMR to analyse…
[...]Thevis M, Schrader Y, Thomas A, Sigmund G, Geyer H, Schanzer W. Analysis of confiscated black market drugs using chromatographic and mass spectrometric approaches. J Anal Toxicol. 2008;32(3):232-240.
In the context of house searches in Germany, numerous drugs were confiscated and subjected to chemical analysis, including anabolic agents such as various anabolic-androgenic steroids (stanozolol, testosterone derivatives, trenbolone esters, etc.) and clenbuterol, as well as agents with anti-estrogenic activity (tamoxifen, clomiphene), drugs stimulating virility (sildenafil, tadalafil), and unlabeled plastic bags. Liquid chromatography-tandem mass spectrometry,…
[...]Shi YQ, Yao J, Liu F, Hu CQ, Yuan J, Zhang QM, Jin SH. Establishment of an HPLC identification system for detection of counterfeit steroidal drugs. J Pharm Biomed Anal. 2008;46(4):663-9.
A set of simple HPLC methods employing UV detection were developed for detection of counterfeit drugs by the qualitative and quantitative analysis of nine steroidal drugs, ethinylestradiol, diethylstilbestrol, norethisterone, norgestrel, methyltestosterone, medroxyprogesterone acetate, progesterone, testosterone propionate and nilestriol. The methods were based on studies of the relationships between the retention factors (k) of the nine…
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